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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
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Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Related Experiment Video

Updated: Sep 24, 2025

Characterization of Blood Outgrowth Endothelial Cells BOEC from Porcine Peripheral Blood
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Big picture initiatives in bleeding disorders.

Antoine Rauch1, Leonard A Valentino2,3, Kevin Mills2

  • 1CHU Lille, Hematology Transfusion, LILLE, France.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|May 6, 2022
PubMed
Summary

The National Hemophilia Foundation (NHF) developed a research agenda to address gaps in inherited bleeding disorders (IBD) care. This blueprint prioritizes health equity and specific needs for women with IBDs.

Keywords:
heavy menstrual bleedinginherited bleeding disorderspostpartum haemorrhagepregnancy

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Last Updated: Sep 24, 2025

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Area of Science:

  • Hematology
  • Medical Research
  • Public Health

Background:

  • Recent therapeutic advances in inherited bleeding disorders (IBD) have occurred.
  • Significant gaps in care persist, especially for rare disorders and underserved populations.

Purpose of the Study:

  • To establish a national research blueprint agenda led by the National Hemophilia Foundation (NHF).
  • To enhance patient-centric principles and accelerate research for IBDs.
  • To address critical knowledge and care gaps for women with IBDs.

Main Methods:

  • Community input from patients, caregivers, research leaders, and industry representatives informed the NHF blueprint agenda.
  • Two medical experts conducted a comprehensive review to identify knowledge gaps in women with IBDs.

Main Results:

  • The NHF blueprint is founded on principles of addressing key issues impacting individuals with IBDs and achieving health equity.
  • A multidisciplinary approach is crucial for managing puberty, transition to adulthood, and pregnancy in IBDs.
  • Women with IBDs continue to experience a high burden of disease despite adherence to guidelines.

Conclusions:

  • The NHF blueprint will be released in 2022.
  • A dedicated research agenda for women with IBDs is essential to improve their management and quality of life.