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Related Concept Videos

Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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The hydration of cement is an exothermic reaction in which heat is generated as cement hydrates. This heat of hydration is critical to cement's strength development. The rate at which this heat is generated affects the temperature rise, with a majority of the heat being released early in the hydration process, half within the first three days, and about 75% within the first week.
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Updated: Sep 24, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
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Exertional heat stroke: nutritional considerations.

Jason K W Lee1,2,3,4,5,6,7,8, Beverly Tan1,8, Henry B Ogden9,10

  • 1Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Experimental Physiology
|May 6, 2022
PubMed
Summary
This summary is machine-generated.

Nutrition plays a key role in exertional heat stroke (EHS), a serious condition affecting physically active individuals. Certain dietary strategies may protect against EHS, while others increase risk, necessitating further research into nutritional countermeasures.

Keywords:
exerciseheat stresssupplements

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Area of Science:

  • Sports Medicine
  • Environmental Physiology
  • Nutritional Science

Background:

  • Exertional heat stroke (EHS) is a critical illness impacting athletes, military personnel, and laborers in hot conditions.
  • Mitigation strategies for EHS traditionally focus on environmental and physiological factors, with nutrition being largely overlooked.
  • Climate change is projected to increase the incidence of EHS, highlighting the need for comprehensive prevention strategies.

Purpose of the Study:

  • To review the pathophysiology of EHS.
  • To examine the influence of nutritional and dietary strategies on EHS risk.
  • To identify potential nutritional countermeasures and recommend future research directions.

Main Methods:

  • Literature review of existing research on EHS and nutrition.
  • Analysis of how specific nutrients and dietary patterns impact EHS pathophysiology.
  • Synthesis of evidence on protective and detrimental nutritional factors.

Main Results:

  • Certain nutritional strategies, such as carbohydrate intake, proper hydration, and glutamine supplementation, may offer protection against EHS.
  • Conversely, some nutritional factors and low energy availability can exacerbate EHS risk.
  • Evidence suggests that while some dietary practices may mitigate EHS, more human studies are needed to confirm their efficacy.

Conclusions:

  • Nutrition is an underexplored but significant factor in EHS.
  • Optimizing dietary intake could serve as a valuable countermeasure to reduce EHS incidence and severity.
  • Further research is crucial to validate nutritional interventions for EHS prevention in humans.