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Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Related Experiment Video

Updated: Sep 24, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

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The roles of inter-tissue adhesion in development and morphological evolution.

Sarah Jacquelyn Smith1, Emilie Guillon1, Scott A Holley1

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Journal of Cell Science
|May 6, 2022
PubMed
Summary

Inter-tissue adhesion, the physical interaction between neighboring tissues, plays crucial roles in animal development and evolution. This process influences tissue movement, shape, and diversification across species.

Keywords:
AdhesionCadherinExtracellular matrixIntegrinMorphogenesis

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Area of Science:

  • Cell Biology
  • Biophysics
  • Developmental Biology

Background:

  • Inter-tissue adhesion involves physical interactions between adjacent tissues.
  • It can be mediated by cell-extracellular matrix or cell-cell adhesion.
  • Studies have explored its mechanisms and consequences in various species.

Purpose of the Study:

  • To review recent advances in understanding the functions of inter-tissue adhesion.
  • To highlight its roles in animal development and evolution.

Main Methods:

  • This review synthesizes findings from existing in vivo studies.
  • It examines research across vertebrate and invertebrate species.

Main Results:

  • Inter-tissue adhesion couples tissue motion, constrains morphogenesis, and transmits tension.
  • It can induce tissue folding, facilitate invasion, and generate friction for tissue positioning.
  • Adhesion contributes to the diversification of animal morphologies.

Conclusions:

  • Inter-tissue adhesion is a fundamental process with diverse functions in development.
  • It significantly contributes to evolutionary diversification of animal forms.