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Human pluripotent stem cell registry: Operations, role and current directions.
Andreas Kurtz1,2, Nancy Mah1, Ying Chen1
1Fraunhofer Institute for Biomedical Engineering, Sulzbach, Germany.
Cell Proliferation
|May 6, 2022
Summary
The human pluripotent stem cell registry (hPSCreg) offers a transparent, quality-assessed resource for human embryonic and induced pluripotent stem cells (hESC, hiPSC). It aims to improve research reproducibility and data interoperability globally.
Area of Science:
- Stem Cell Biology
- Bioinformatics
- Data Management
Background:
- The human pluripotent stem cell registry (hPSCreg) was established as a global, publicly accessible database.
- It aims to provide transparent, quality-assessed human embryonic stem cell (hESC) and induced pluripotent stem cell (hiPSC) lines.
- The registry seeks to enhance research reproducibility and data interoperability.
Purpose of the Study:
- To review the establishment, mission, and development of hPSCreg into a comprehensive knowledgebase.
- To detail the data categories available within hPSCreg.
- To discuss current hPSC-focused databases, data sharing practices, and associated challenges.
Main Methods:
- Review of the hPSCreg database and its functionalities.
- Analysis of data categories and structure within hPSCreg.
- Examination of global data sharing initiatives and obstacles in the field of stem cell research.
Main Results:
- hPSCreg serves as a vital resource for quality-assessed hPSC lines.
- The database facilitates data sharing and promotes research reproducibility.
- Current challenges and future directions for hPSC data management are identified.
Conclusions:
- hPSCreg has evolved into a crucial knowledgebase for stem cell research.
- Future developments may involve digital donor representatives and repositioning databases as mediators.
- Enhanced data integration and sharing are essential for advancing stem cell science.
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