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Published on: November 6, 2020
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Sivelestat's effect on Candida albicans water-soluble fraction-induced vasculitis
Yuya Yoshida1, Rie Banno-Terada1,2, Masashi Takada1
1Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Summary
Sivelestat sodium hydrate (SSH) effectively treated vasculitis in a mouse model of Kawasaki disease by reducing inflammation and preventing coronary artery lesions. SSH may also target monocytes, in addition to its known neutrophil elastase inhibition.
Area of Science:
- Immunology
- Pharmacology
- Cardiovascular Research
Background:
- Kawasaki disease is an inflammatory condition affecting coronary arteries.
- Investigating novel therapeutic targets for vasculitis is crucial.
- Sivelestat sodium hydrate (SSH) is a potential treatment for inflammatory diseases.
Purpose of the Study:
- To evaluate the efficacy of SSH in a mouse model of Kawasaki disease.
- To elucidate the pharmacological action sites of SSH in vasculitis.
Main Methods:
- Mice with Candida albicans water-soluble fraction-induced vasculitis were treated with SSH.
- Efficacy was assessed by measuring coronary artery lesions and inflammatory cell infiltration.
- Pharmacological actions were studied by analyzing neutrophil elastase (NE), intercellular adhesion molecule 1 (ICAM-1), and monocyte behavior.
Main Results:
- SSH treatment significantly reduced vasculitis scores, indicating prevention of coronary artery lesions.
- SSH decreased NE and ICAM-1 expression and ICAM-1/TNF-α mRNA levels.
- SSH increased peripheral blood monocyte proportion but suppressed their migration to inflamed areas.
Conclusions:
- SSH demonstrates potential in preventing coronary artery lesions and reducing disease activity in vasculitis.
- SSH's mechanism involves NE inhibition and may extend to modulating monocyte function.
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