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Related Experiment Video

Updated: Sep 24, 2025

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
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Engineering multiscale structural orders for high-fidelity embryoids and organoids.

Yue Shao1, Jianping Fu2

  • 1Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.

Cell Stem Cell
|May 6, 2022
PubMed
Summary

Developing high-fidelity embryoids and organoids requires advanced bioengineering frameworks. These models are crucial for understanding human development and advancing translational medicine.

Keywords:
developmental biologyembryoidmammalian embryogenesismechanobiologyorganoidstem cell engineering

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Area of Science:

  • Developmental Biology
  • Bioengineering
  • Regenerative Medicine

Background:

  • Embryoids and organoids are promising models for studying human biology and disease.
  • High-fidelity models are needed to accurately represent tissue and organ functions.
  • Understanding mammalian embryogenesis provides a foundation for building these models.

Purpose of the Study:

  • To discuss conceptual and technological frameworks for creating high-fidelity embryoids and organoids.
  • To review progress in reconstructing multiscale structural orders in these models.
  • To highlight bioengineering approaches for next-generation developmental models.

Main Methods:

  • Dissecting the layers of inputs controlling mammalian embryogenesis.
  • Reviewing recent progress in reconstructing multiscale structural orders.
  • Discussing bioengineering tools for structural engineering of cellular organization and microenvironment.

Main Results:

  • Progress has been made in reconstructing multiscale structural orders in embryoids and organoids.
  • Bioengineering tools enable multiscale, multimodal structural engineering.
  • Integrative, bioengineering-directed approaches are presented.

Conclusions:

  • High-fidelity embryoids and organoids are achievable through advanced bioengineering.
  • These models are critical for decoding developmental programs.
  • Improved models will enhance translational applications in medicine.