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Systematic review on fecal calprotectin in cystic fibrosis
Eduarda Sampaio Lazzarotto1, Jannaina Ferreira de Melo Vasco1, Fabiane Führ2
1Universidade Federal do Paraná, Curitiba, PR, Brazil.
Objectives:
Fecal calprotectin is an inflammatory marker used for monitoring intestinal diseases. It has been studied as a marker of intestinal inflammation in cystic fibrosis (CF), a multi-systemic genetic disease caused by alterations to the CFTR gene. Manifestations of the disease favor a systemic inflammation not limited to the respiratory tract, therefore, calprotectin is a non-invasive and effective diagnostic method. The aim of the study was to perform a systematic review of the literature with a qualitative synthesis of studies.
Sources:
The articles were selected from PubMed, Web of Science, Scielo and Lilacs.
Summary Of The Findings:
Nine studies were selected for that qualitative synthesis, one was a randomized clinical trial, and eight were case-control or cohort designs. Most studies have indicated that calprotectin is a marker of systemic inflammation in CF and not just intestinal inflammation. Calprotectin is an aid in monitoring inflammatory bowel conditions in patients with cystic fibrosis.
Conclusion:
Further studies should be conducted to investigate the role of this marker in the systemic inflammation of CF.
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