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Related Experiment Videos

Applied potential tomography: a new non-invasive technique for assessing gastric function.

Y F Mangnall, A J Baxter, R Avill

    Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Fur Medizinische Physik and the European Federation of Organisations for Medical Physics
    |January 1, 1987
    PubMed
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    Applied potential tomography (APT) accurately measures gastric emptying of liquid and solid foods. This non-invasive, inexpensive technique is reproducible and suitable for various patient groups, offering a potential alternative to traditional methods.

    Area of Science:

    • Medical Imaging
    • Gastroenterology
    • Biophysics

    Background:

    • Gastric emptying measurement is crucial for diagnosing and managing gastrointestinal disorders.
    • Existing methods like scintigraphy and dye dilution have limitations, including invasiveness and cost.

    Purpose of the Study:

    • To validate Applied Potential Tomography (APT) as a non-invasive method for measuring gastric emptying.
    • To assess the accuracy and reproducibility of APT for liquid and semi-solid meals.
    • To explore APT's potential for measuring gastric acid secretion.

    Main Methods:

    • In vitro experiments correlating resistivity measurements with known volumes and shapes.
    • In vivo studies measuring gastric emptying of liquid and mashed potato meals using APT.

    Related Experiment Videos

  • Comparison of APT results with scintigraphy, dye dilution, and direct acid secretion measurements.
  • Inhibition of gastric acid secretion using cimetidine to improve reproducibility.

    • Main Results:

    • Excellent correlation between resistivity and volume/radius in vitro.
    • APT gastric emptying profiles closely matched scintigraphy and dye dilution for liquid meals (with cimetidine).
    • APT profiles also mirrored scintigraphy for mashed potato meals.
    • Reproducible measurements of liquid meal emptying when acid secretion was inhibited.
    • Good correlation between resistivity changes and measured gastric acid secretion.

    Conclusions:

    • Applied Potential Tomography (APT) is an accurate, reproducible, and non-invasive method for assessing gastric emptying of liquids and solids.
    • APT is well-tolerated, cost-effective, and suitable for frequent patient studies, including pregnant individuals.
    • APT shows promise as a non-invasive alternative for gastric acid secretion measurement, potentially replacing nasogastric intubation.