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Checkpoint inhibitors in a marriage: consented or arranged?
Patrick Brest1, Sadal Refae2, Baharia Mograbi1
1Université Côte d'Azur, Centre Antoine Lacassagne, CNRS, Inserm, IRCAN, FHU-OncoAge, F-06189, Nice, France.
Abstract:
There is currently a strong development of therapeutic combinations with checkpoint inhibitors (CPIs). The most promising combinations with CPIs concern anti-angiogenic agents and BRAF/MEK inhibitors. The timing of the initiation of the combination should be particularly well investigated for chemotherapy. Combinations between CPIs raise questions about risk/benefit ratio and overall clinical activity.
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