ISSLS Prize in Bioengineering Science 2022: low rate cyclic loading as a therapeutic strategy for intervertebral disc...

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Spinal Research

Background:

• Intervertebral disc degeneration is age-related with limited natural regeneration.
• Small molecule transport is critical for disc repair and degradation.
• Low rate cyclic loading enhances small molecule transport in discs.

Purpose of the Study:

• To evaluate if daily low rate cyclic loading can slow, halt, or reverse intervertebral disc degeneration.
• To investigate the therapeutic potential of mechanical loading on degenerated discs.

Main Methods:

• A rabbit lumbar spine model was used with puncture-induced degeneration.
• Groups included Control, degeneration (8D, 16D), and therapy (degeneration + cyclic loading).
• Evaluations included T2 mapping, Pfirrmann grading, nucleus volume, disc height, morphology, and proteoglycan content.

Main Results:

• The therapy group showed intermediate results between control and degenerated groups across all metrics.
• Sustained low rate cyclic loading demonstrated a therapeutic effect on degenerated discs.
• The regimen promoted observable signs of disc regeneration.

Conclusions:

• Sustained low rate cyclic loading has a therapeutic effect on degenerated intervertebral discs.
• This mechanical loading approach shows potential for promoting disc regeneration.
• This non-invasive method could address a significant clinical need for treating disc degeneration.