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Updated: Sep 24, 2025
12:13
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
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TNFRSF13B is a potential contributor to prostate cancer
Chia-Yang Li1,2, Shu-Pin Huang3,4,5,6, Yei-Tsung Chen7
1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Cancer Cell International
|May 6, 2022
Summary
Genetic variants in immunodeficiency genes, particularly TNFRSF13B, are linked to prostate cancer recurrence. Lowering TNFRSF13B expression reduced cancer cell growth, suggesting its role in prostate cancer progression.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Immunodeficiencies predispose individuals to cancer due to impaired anti-tumor immunity.
- The specific relationship between immunodeficiency and prostate cancer progression is not well understood.
- Prostate cancer recurrence after radical prostatectomy is a significant clinical concern.
Purpose of the Study:
- To investigate the impact of genetic variations in eight immunodeficiency pathway genes on prostate cancer recurrence.
- To explore the functional role of TNFRSF13B in prostate cancer cell behavior.
- To elucidate the molecular mechanisms by which TNFRSF13B influences prostate cancer progression.
Main Methods:
- Genetic analysis of 19 single-nucleotide polymorphisms in 458 prostate cancer patients post-radical prostatectomy.
- TNFRSF13B knockdown in prostate cancer cell lines (22Rv1, PC-3) using short hairpin RNAs.
- Cell proliferation, colony formation assays, and microarray gene expression profiling to assess TNFRSF13B function and molecular pathways.
Main Results:
- The TNFRSF13B rs4792800 polymorphism was significantly associated with biochemical recurrence (aHR 1.78, p=0.008).
- The G allele correlated with higher TNFRSF13B expression, which was linked to poor prognosis in independent datasets.
- Silencing TNFRSF13B reduced prostate cancer cell proliferation and colony formation by modulating cell cycle and p53 pathways.
Conclusions:
- Immunodeficiency pathway-related genes, especially TNFRSF13B, may play a crucial role in prostate cancer progression.
- TNFRSF13B rs4792800 serves as a potential genetic marker for predicting prostate cancer recurrence.
- Targeting TNFRSF13B could offer a novel therapeutic strategy for prostate cancer.
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