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The risk factors of preterm birth: A multicentre case-control survey in China in 2018

Yi-Jie Zhang1, Jieru Shen1, Sam Bill Lin1

  • 1Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.

Journal of Paediatrics and Child Health
|May 7, 2022
PubMed

Insights

Preterm birth (PTB) in China is significantly linked to placental issues, hypertensive disorders, and multiple pregnancies. Lifestyle, psychological factors, and socioeconomic disadvantages also pose major risks.

Area of Science:

  • Obstetrics and Gynecology
  • Public Health
  • Epidemiology

Background:

  • Preterm birth (PTB) remains a significant global health concern.
  • Understanding the specific risk factors for PTB in diverse populations is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the risk profile of preterm birth (PTB) in China in 2018.
  • To identify key maternal, fetal, and socioeconomic factors associated with PTB.

Main Methods:

  • A prospective multicentre case-control study involving 3147 preterm and 3147 term live-birth mothers across China.
  • Data collected via questionnaires on maternal and fetal information.
  • Multivariable logistic regression and population attributable risk (PAR) were calculated.

Main Results:

  • Iatrogenic PTB constituted 48.1% of preterm births.
  • Significant PTB risk factors included placental abnormality, hypertensive disorders in pregnancy, and multiple pregnancy.
  • Adverse lifestyle/psychological conditions and lower education levels showed high population attributable risk (PAR).

Conclusions:

  • Placental abnormality, hypertensive disorders, and multiple pregnancy are primary PTB risk factors in China.
  • Adverse lifestyle, psychological conditions, and socioeconomic disadvantages represent significant public health challenges for PTB prevention.
Abstract

Keywords:
Chinamulticentre surveypopulation attributable riskpreterm birthrisk factors

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