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Published on: May 18, 2022
Hormesis is an evolutionary expectation: implications for aging
Edward J Calabrese1, Evgenios Agathokleous2
1School of Public Health and Health Sciences Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA. edwardc@schoolph.umass.edu.
Abstract:
This article argues that evolution and the concept of hormesis are biologically inseparable. It proposes that evolutionary processes led to the selection of inducible adaptive hormetic strategies that are necessary for wellbeing and survival. Hormesis has been demonstrated in essentially all organisms in which it has been studied from bacteria to humans, showing its highly conserved features. This evolution-hormesis integration should be a central feature in both understanding the biology of aging but also in ways to enhance improved health-based aging strategies.
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