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Updated: Sep 24, 2025

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine DOPA and Its Application to Protein Conjugation

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine DOPA and Its Application to Protein Conjugation

Published on: August 24, 2018

Polydopamine at biological interfaces.

Maria Laura Alfieri¹, Tanja Weil², David Yuen Wah Ng²

¹Department of Chemical Sciences, University of Naples Federico II, Via Cintia 21, I-80126 Naples, Italy.

Advances in Colloid and Interface Science

|May 7, 2022

Summary

This summary is machine-generated.

Polydopamine coatings are versatile and can be functionalized with biomolecules. Recent research explores these polydopamine-biomolecule composites, including their interactions with living cells.

Keywords:

Biomolecules Catecholamines Nanocomposites Polydopamine

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Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Published on: November 14, 2018

Area of Science:

Materials Science
Biochemistry
Surface Chemistry

Background:

Polydopamine (PDA) coatings are a popular, versatile method for surface functionalization.
PDA offers rich chemistry for post-modification with nanoparticles, polymers, and proteins.
Interactions between PDA and biomolecules are a recent area of exploration.

Purpose of the Study:

To review recent advances in designing composites of polydopamine and related eumelanin-like materials with biomolecules.
To discuss interactions between polydopamine and biomolecules such as proteins, nucleotides, oligosaccharides, and lipid assemblies.
To report on the interactions between polydopamine and living cells.

Main Methods:

Literature review of recent scientific publications.
Analysis of studies on polydopamine synthesis and functionalization.
Exploration of research on polydopamine-biomolecule composite formation and characterization.

Main Results:

Polydopamine serves as a platform for creating advanced biomolecular composites.
Covalent and non-covalent interactions enable diverse PDA-biomolecule assemblies.
PDA-based materials show promise in cell interactions and biomedical applications.

Conclusions:

Polydopamine is a significant biomaterial for developing novel composites.
Understanding PDA-biomolecule interactions is crucial for advanced applications.
Future research directions include exploring PDA's role in cellular environments.