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Towards more efficient ophthalmic disease classification and lesion location via convolution transformer
Huajie Wen1, Jian Zhao2, Shaohua Xiang2
1College of Big Data and Internet, Shenzhen Technology University, Shenzhen 518118, China; College of Applied Science, Shenzhen University, Shenzhen 518060, China.
Computer Methods and Programs in Biomedicine
|May 7, 2022
Summary
This study introduces a new deep learning method combining convolution and self-attention for better analysis of retina optical coherence tomography (OCT) images. The LLCT model improves disease classification and lesion localization, aiding ophthalmologists.
Area of Science:
- Ophthalmology
- Medical Imaging
- Artificial Intelligence
Background:
- Retina optical coherence tomography (OCT) images present challenges like speckle noise and subtle features, hindering accurate diagnosis with conventional methods.
- Existing deep learning models struggle with the unique characteristics of OCT images, limiting classification accuracy and diagnostic utility.
Purpose of the Study:
- To develop a novel deep learning method, the lesion-localization convolution transformer (LLCT), for enhanced classification and lesion localization in retina OCT images.
- To address the limitations of traditional deep learning architectures in analyzing noisy and complex OCT image data.
Main Methods:
- A hybrid architecture integrating convolutional neural networks (CNNs) for feature extraction with self-attention mechanisms for global context analysis.
- Customized feature maps from CNNs serve as input sequences for the self-attention network, leveraging both local and global image information.
- A unique lesion localization mechanism utilizes backpropagation gradients combined with forward-propagated global features.
Main Results:
- The LLCT method demonstrated significant improvements: 7.6% in overall accuracy, 10.9% in sensitivity, and 9.2% in specificity compared to existing approaches.
- Effective localization of lesions within OCT images was achieved without requiring pre-labeled lesion location data.
- The model reduces computational complexity in AI-assisted ophthalmic disease analysis.
Conclusions:
- The proposed LLCT method substantially enhances the performance of AI-assisted ophthalmic disease analysis using OCT images.
- This approach offers a significant advancement in classifying and locating ophthalmic diseases, providing valuable assistance to ophthalmologists.

