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Anhedonia reduction correlates with increased ventral caudate connectivity with superior frontal gyrus in depression
Xinhua Yang1, Jia Huang2, Matthew E Roser3
1Shanghai Changning Mental Health Center, Shanghai, China; Brain Research & Imaging Centre, School of Psychology, Cognition Institute, Faculty of Health & Human Sciences, Plymouth University, UK.
Abstract:
This study was to investigate the relationship between the ventral caudate connectivity and anhedonia. Nineteen depressed patients and 16 healthy controls participated in two identical functional magnetic resonance imaging scans during a 1-year period to determine the resting-state functional connectivity changes using a seed-based approach. Patients showed increased left ventral caudate functional connectivity with superior frontal gyrus over time and the increased connectivity was associated with anhedonia improvement. None of these associations were observed in healthy controls. The findings suggest that left ventral caudate may serve as a potential target to improve the severity of anhedonia.
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