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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Lymph Node Colonization Induces Tumor-immune Tolerance To Promote Distant Metastasis.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Lymph Node Colonization Induces Tumor-immune Tolerance To Promote Distant Metastasis.

Related Experiment Video

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.

Nathan E Reticker-Flynn1, Weiruo Zhang2, Julia A Belk1

  • 1Department of Pathology, Stanford University, Stanford, CA 94305, USA.

Cell
|May 7, 2022

View abstract on PubMed

Summary
This summary is machine-generated.

Lymph node metastasis in solid tumors actively promotes distant spread. Tumors in lymph nodes evade immune responses and induce tolerance, facilitating further colonization and systemic disease progression.

Keywords:
ISGsMHC-INK cellsPD-L1

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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

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Related Experiment Videos

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Metastasis

Background:

  • Lymph node (LN) involvement is a key prognostic factor in solid malignancies, indicating distant metastatic potential.
  • The active role of LN metastasis in shaping distant metastasis remains poorly understood.

Purpose of the Study:

  • To investigate the mechanisms of tumor spread to LNs.
  • To determine if LN colonization influences metastasis to distant tissues.

Main Methods:

  • Development of a syngeneic melanoma mouse model of LN metastasis.
  • Analysis of tumor-intrinsic interferon response programs.
  • Assessment of immune evasion and colonization dynamics within LNs.

Main Results:

Tregs
interferon
lymph nodes
metastasis
regulatory T cells
tolerance
  • An epigenetically regulated, tumor-intrinsic interferon response enhances LN metastatic potential.
  • This response facilitates evasion of Natural Killer (NK) cells and promotes LN colonization.
  • LN metastases resist T cell-mediated killing, induce regulatory T cells, and establish immune tolerance, promoting distant colonization.

    • Conclusions:

    • LN metastasis actively promotes distant spread through immune evasion and tolerance induction.
    • This mechanism is conserved across different cancer types and species.
    • Understanding this process offers potential therapeutic targets for managing metastatic disease.