Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipoprotein lipase in diabetes.

M R Taskinen

    Diabetes/Metabolism Reviews
    |April 1, 1987
    PubMed
    Summary

    Lipoprotein lipase (LPL) activity is insulin-dependent and crucial for managing blood lipids in diabetes. Insulin therapy improves LPL activity, positively impacting triglyceride and HDL cholesterol levels in both Type 1 and Type 2 diabetes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetically determined increase in apolipoprotein C-III (APOC3 gain-of-function) delays very low-density lipoprotein clearance in humans.

    Atherosclerosis·2025
    Same author

    Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins.

    Obesity (Silver Spring, Md.)·2013
    Same author

    Response letter to D. Singh-franco et al.

    Diabetes, obesity & metabolism·2012
    Same author

    Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.

    Diabetologia·2011
    Same author

    Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.

    Diabetologia·2007
    Same author

    Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus.

    Diabetologia·2007

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Metabolic Research

    Background:

    • Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism, influencing triglyceride-rich particles and high-density lipoproteins (HDL).
    • LPL activity in adipose and skeletal muscle is modulated by insulin, making it sensitive to glycemic control in diabetes.

    Purpose of the Study:

    • To investigate the role and regulation of lipoprotein lipase (LPL) activity in patients with Type 1 and Type 2 diabetes.
    • To correlate LPL activity with serum lipid profiles, including triglycerides and HDL concentrations, under various glycemic control conditions.

    Main Methods:

    • Enzyme activity assays of lipoprotein lipase (LPL) in postheparin plasma, adipose tissue, and skeletal muscle.
    • Analysis of serum lipid levels (triglycerides, HDL cholesterol) in diabetic patients with different insulin statuses and glycemic control.

    Main Results:

    • In untreated Type 1 diabetes, LPL activity is low but increases with insulin therapy.
    • Good glycemic control in both Type 1 and Type 2 diabetes, via insulin or oral agents, is associated with increased LPL activity.
    • Altered LPL activity correlates with dyslipidemia: low LPL is linked to elevated triglycerides and reduced HDL, while high LPL is associated with normalized or reduced triglycerides and increased HDL.

    Conclusions:

    • Lipoprotein lipase (LPL) activity is a significant factor in the dyslipidemia observed in diabetes.
    • Restoring adequate insulin levels and glycemic control can enhance LPL activity, leading to improved lipoprotein profiles.

    Related Experiment Videos