Amelioration of Cd-induced bioaccumulation, hematological parameters, and heat shock protein-related genes by Vitamin...

The heavy metal cadmium (Cd) is a kind of non-essential toxic environmental pollutant with extremely long biological half-life, various toxic and sublethal effects on aquatic organisms, and many adverse effects on the organs of human and other mammals. Vitamin C is an essential micronutrient in aquatic feed, and an indispensable nutrient for maintaining physiological processes in different animals, including fish. The aim of this study was to evaluate the effects of administration of Vitamin C on bioaccumulation, hematological parameters and heat shock protein-related genes of common carp following Cd exposure. The fish were exposed to waterborne Cd at 0, 1 and 2 mg/L and administration Vitamin C at 150 and 300 mg/kg for 8 weeks. The results obtained indicate that Vitamin C can provide a significant protective effect on the toxicity of cadmium by inhibiting alterations in the levels of bioaccumulation, hematological parameters (including calcium, magnesium, glucose, alkaline phosphatase (ALP), glutamic-pyruvic transaminase (ALT), aspartate transaminase (AST), total protein, lactate dehydrogenase (LDH), cholesterol and lysozyme (LZM)) and heat shock protein-related genes (Hsp70, Hsp90, Hsp47 and Hsp60). Our study demonstrates that vitamin C has the potential to reduce heavy metal damage to common carp and improve immunity.