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Related Concept Videos

Maximum Size of Aggregate01:12

Maximum Size of Aggregate

249
The maximum size of aggregate is defined as the aperture of the sieve retaining 15 percent or more of the particles present in the aggregate sample. The aggregate's maximum size impacts the concrete's water requirement, workability, and strength. Larger aggregates reduce the surface area needing cement paste coverage, which can lower water needs, thereby allowing a decrease in the water-to-cement ratio when the desired workability and richness of the mix are to be maintained, which can...
249
Aggregates Classification01:29

Aggregates Classification

397
Aggregate classification is generally based on its size, petrographic characteristics, weight, and source. Size classification ranges from coarse to fine aggregates, defined by the size of the particles. Coarse aggregates are particles that do not pass through ASTM sieve No. 4, and aggregates that pass through the sieve are fine aggregates.
Petrographic classification groups aggregates based on common mineralogical characteristics. Some of the common mineral groups found in aggregates are...
397
Unsoundness of Aggregate due to Volume Change01:26

Unsoundness of Aggregate due to Volume Change

190
Unsoundness in aggregates due to volume changes is primarily caused by the physical alterations aggregates undergo, such as freezing and thawing, thermal changes, and wetting and drying. Unsound aggregates, when subjected to these changes, result in volume change upon disintegration. This, in turn, contributes to the deterioration of concrete, including scaling, pop-outs, and cracking. Particular types of aggregates, such as porous flints, cherts, and those containing clay minerals, are...
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Related Experiment Video

Updated: Sep 24, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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Tau Aggregation.

Félix Hernández1, Isidro Ferrer2, Mar Pérez3

  • 1Centro de Biología Molecular 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, Spain.

Neuroscience
|May 7, 2022
PubMed
Summary

This study examines tau protein aggregation across all structural levels, including primary, secondary, tertiary, and quaternary. It also discusses the recently identified non-aggregated tau protein.

Keywords:
microtubule-binding repeatstautau conformationsw-tau isoform

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Related Experiment Videos

Last Updated: Sep 24, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

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Published on: January 2, 2015

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Structural Biology

Background:

  • Tau protein is implicated in neurodegenerative diseases.
  • Protein aggregation is a hallmark of many neurological disorders.
  • Understanding tau structure is crucial for disease mechanisms.

Purpose of the Study:

  • To re-examine tau protein aggregation at all structural levels.
  • To incorporate the role of non-aggregated tau protein.
  • To provide a comprehensive overview of tau protein structure and aggregation.

Main Methods:

  • Literature review and analysis of existing structural data.
  • Discussion of biochemical and biophysical properties of tau.
  • Synthesis of current research on tau aggregation.

Main Results:

  • Tau aggregation occurs across primary, secondary, tertiary, and quaternary structures.
  • Non-aggregated tau protein exists and its role is considered.
  • Detailed structural insights into tau aggregation pathways are presented.

Conclusions:

  • Tau protein aggregation is a complex process involving multiple structural levels.
  • The non-aggregated form of tau protein warrants further investigation.
  • A comprehensive understanding of tau structure is essential for therapeutic strategies.