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Updated: Sep 24, 2025

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Has anything changed in Evidence-Based Medicine?

George D Chloros1, Apostolos D Prodromidis1, Peter V Giannoudis2

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Evidence-Based Medicine (EBM) integrates evidence, expertise, and patient values. Recent changes, accelerated by COVID-19, have updated EBM

Keywords:
COVID-19Evidence based medicineEvidence pyramidEvidence-based researchLevels of evidence

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Area of Science:

  • Medical Informatics
  • Clinical Practice Guidelines
  • Health Services Research

Background:

  • The Evidence-Based Medicine (EBM) movement, established in the 1990s, revolutionized medical practice by emphasizing evidence, clinical expertise, and patient values.
  • While EBM's core principles remain robust, its implementation has been significantly impacted by the digital information age and the COVID-19 pandemic.

Purpose of the Study:

  • To provide a concise update on the evolution of Evidence-Based Medicine (EBM).
  • To highlight significant recent changes in EBM implementation, particularly those expedited by the COVID-19 crisis.

Main Methods:

  • Review of literature on Evidence-Based Medicine (EBM) evolution.
  • Analysis of practical implementation shifts in EBM.
  • Identification of COVID-19's impact on EBM practices.

Main Results:

  • EBM's theoretical framework is stable, but practical application has transformed.
  • The "electronic explosion" of information necessitates new EBM approaches.
  • The COVID-19 pandemic accelerated the adoption of rapid evidence synthesis and digital health tools in EBM.

Conclusions:

  • Evidence-Based Medicine (EBM) continues to adapt to the modern healthcare landscape.
  • The integration of digital resources and agile methodologies is crucial for contemporary EBM.
  • Future EBM practices will likely incorporate lessons learned from the pandemic to enhance responsiveness and accessibility.