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Adjunctive vitamin D therapy in various diseases in children: a scenario according to standard guideline
Hafsa Arshad1, Faiz Ullah Khan2, Naveed Ahmed3
1Department of Pharmacy Quaid-i-Azam University, Islamabad, 45320, Pakistan. hafsaarshad46@gmail.com.
Insights
This study found poor adherence to vitamin D guidelines in pediatric disease management. Low socioeconomic status significantly impacts vitamin D supplementation consumption in children and mothers.
Area of Science:
- Pediatric Endocrinology
- Clinical Practice Guidelines
- Public Health Nutrition
Background:
- Standard guidelines are crucial for effective disease management.
- Adjunctive vitamin D therapy is used in various pediatric diseases.
- The influence of socioeconomic status on vitamin D consumption requires investigation.
Purpose of the Study:
- To evaluate the administration of adjunctive vitamin D therapy in pediatric diseases.
- To assess adherence to standard guidelines for vitamin D therapy.
- To examine the effect of socioeconomic status on vitamin D consumption in children.
Main Methods:
- A cross-sectional observational study of 400 pediatric patients.
- Data collected via structured questionnaire from medical charts.
- Adherence evaluated against U.S. endocrinology guidelines; socioeconomic status association analyzed using chi-square.
Main Results:
- Adjunctive vitamin D therapy was prescribed for 9 diseases and 21 comorbidities.
- Low adherence to vitamin D testing was noted in high-risk diseases (e.g., seizures 3.8%, meningitis 14.3%).
- Adherence to prescribed vitamin D dosage was 41.3%; significant association found between socioeconomic status and vitamin D consumption.
Conclusions:
- Adjunctive vitamin D is prescribed across various pediatric conditions.
- Overall adherence to standard vitamin D guidelines in pediatric disease management is poor.
- Low socioeconomic status negatively impacts vitamin D supplementation intake in children.
Background:
Adherence to standard guidelines is imperative when question comes to disease management. The present study aimed to evaluate the administration of adjunctive vitamin D therapy in various diseases, its adherence to standard guideline and the effect of socioeconomic status on the consumption of vitamin D in children.
Methods:
Cross sectional observational study was conducted among 400 ambulatory pediatric patients at Children's Hospital, Pakistan Institute of Medical Sciences Islamabad, from November 2017 to June 2018. Data were collected by a self-designed structured questionnaire from the patient's medical chart. Adjunctive vitamin D therapy adherence was evaluated by the U. S endocrinology clinical practice guideline of vitamin D deficiency. The association between socioeconomic status and consumption of vitamin D was examined by chi-square. Alpha value (p ≤ 0.005) was considered statistically significant. Statistical analysis was done by SPSS version 25.
Results:
In 400 patients, 9 diseases and 21 comorbid conditions were identified, in which adjunctive vitamin D therapy was prescribed. Adherence to vitamin D testing in high-risk vitamin D deficiency diseases as; seizures (3.8%), bone deformities (13.3%), steroid-resistant nephrotic syndrome (0.0%), cerebral palsy (5.9%) and meningitis (14.3%). Adherence to prescribed vitamin D dose was in (41.3%) patients in various diseases. Significant association (p < 0.05) was found between socioeconomic status and consumption of vitamin D in children and mothers.
Conclusions:
It was found that adjunctive vitamin D was being prescribed in various diseases and comorbidities. Overall poor adherence to the standard guideline was observed in disease management in children. Low socioeconomic status affects vitamin D supplementation consumption in children.
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