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Offspring conceived through ART have normal thyroid function in adolescence and as young adults.

L A Wijs¹, D A Doherty^1,2, J A Keelan^1,2,3

¹Division of Obstetrics and Gynaecology, University of Western Australia, Perth, WA, Australia.

Human Reproduction (Oxford, England)

|May 8, 2022

Summary

This summary is machine-generated.

This study found no clinically significant differences in thyroid function between adolescents conceived with assisted reproductive technology (ART) and those conceived naturally. Thyroid hormone levels remained within normal ranges, suggesting ART does not impact thyroid health in young individuals.

Keywords:

ART ART outcomes ICSI IVF adolescents long-term outcomes thyroid function young adults

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Area of Science:

Endocrinology
Reproductive Medicine
Pediatric Health

Background:

Previous studies suggest a potential increase in subclinical hypothyroidism in offspring conceived via assisted reproductive technology (ART).
Maternal estrogen levels after fresh embryo transfers have been hypothesized to influence fetal thyroid function.
Early detection of thyroid dysfunction is crucial to prevent irreversible neurological damage in young individuals.

Purpose of the Study:

To investigate potential differences in thyroid function between adolescents and young adults conceived with and without ART.
To compare thyroid hormone concentrations and prevalence of thyroid disorders in ART-conceived versus naturally conceived individuals.

Main Methods:

A prospective cohort study (Growing Up Healthy Study) recruited 303 adolescents conceived with ART (aged 13-20 years).
Thyroid assessments (TSH, fT3, fT4, TPOAb) were compared at ages 14 and 20 years with 2868 naturally conceived controls (Raine Study Generation 2).
Analysis included comparisons of mean hormone concentrations, prevalence of thyroid dysfunction, and correlation with maternal estrogen levels.

Main Results:

No clinically relevant differences in thyroid function were observed between the ART-conceived and naturally conceived groups.
While minor differences in fT3 and fT4 were noted at ages 14 and 20, they were not considered biologically significant.
The prevalence of euthyroidism, subclinical/overt hypo- and hyperthyroidism, and thyroid autoimmunity did not differ between groups.

Conclusions:

This study does not support previous findings of clinically significant thyroid function differences in ART-conceived adolescents.
The minor hormonal fluctuations observed are likely not biologically relevant, suggesting reassuring thyroid health outcomes post-ART.
Further research is warranted to investigate thyroid function in ART-conceived individuals throughout adulthood.