Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is the decrease in the hypophysiotropic signal frequency normally observed during the luteal phase important for

N Y Lam, M Ferin

    Endocrinology
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Prostate Health Index in predicting initial prostate biopsy outcomes in Asian men with prostate-specific antigen levels of 4-10 ng/mL.

    International urology and nephrology·2013
    Same author

    The role of urine prostate cancer antigen 3 mRNA levels in the diagnosis of prostate cancer among Hong Kong Chinese patients.

    Hong Kong medical journal = Xianggang yi xue za zhi·2012
    Same author

    Trisomic pregnancy and elevated FSH: implications for the oocyte pool hypothesis.

    Human reproduction (Oxford, England)·2011
    Same author

    Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones.

    CNS spectrums·2004
    Same author

    Trisomic pregnancy and the oocyte pool.

    Human reproduction (Oxford, England)·2004
    Same author

    How about the involvement of a direct hypothalamic-ovarian circuitry?

    Journal of the Society for Gynecologic Investigation·2001

    Altering gonadotropin-releasing hormone (GnRH) pulse frequency during the luteal phase disrupts the primate menstrual cycle. This study shows that manipulating GnRH signaling in rhesus monkeys significantly impacts subsequent cycle length and progesterone secretion.

    Area of Science:

    • Reproductive Endocrinology
    • Neuroendocrinology
    • Primate Physiology

    Background:

    • The ovulatory menstrual cycle in primates involves distinct phases regulated by the GnRH pulse generator.
    • Luteal phase GnRH pulse frequency is notably lower than during the follicular phase.

    Purpose of the Study:

    • To investigate the physiological relevance of reduced luteal phase GnRH pulse frequency on normal menstrual cyclicity.
    • To determine the effects of exogenous pulsatile GnRH administration during the luteal phase on subsequent reproductive cycles in rhesus monkeys.

    Main Methods:

    • Pulsatile GnRH was infused intravenously at hourly intervals for 8-10 days during the luteal phase in eight female rhesus monkeys.
    • Doses of 1.5, 3.0, and 4.0 micrograms/pulse were administered.
    • Subsequent menstrual cycles were monitored for changes in follicular phase length and progesterone secretion.

    Related Experiment Videos

  • Control experiments were conducted under similar conditions without GnRH infusion.

    • Main Results:

    • GnRH therapy during the luteal phase significantly increased subsequent follicular phase length (from 13.4 days in controls to over 23 days in post-treatment cycles).
    • Progesterone secretion was significantly reduced in the first two post-GnRH treatment cycles compared to controls.
    • Luteal phase length remained relatively unchanged despite alterations in cycle dynamics.

    Conclusions:

    • Imposed changes in GnRH pulse frequency during the luteal phase cause significant disturbances in the rhesus monkey menstrual cycle.
    • The naturally occurring decrease in GnRH-LH pulse frequency during the luteal phase is physiologically relevant for controlling menstrual cyclicity.