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Fertility in men with Klinefelter's syndrome
Ingrid Plotton1, Lucie Renault2, Marion Lapoirie3
1Service de Biochimie et Biologie Moléculaire, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France; Service de Médecine de la Reproduction, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Bron, France; Université Claude-Bernard Lyon 1, Lyon, France; Inserm U1208, 18, avenue Doyen-Lépine, 69675 Bron cedex, France.
Annales D'Endocrinologie
|May 8, 2022
Summary
Testicular sperm extraction (TESE) offers fatherhood to men with Klinefelter syndrome (47 XXY). Age impacts sperm retrieval success, with outcomes potentially poorer for those over 30 and before age 16.
Area of Science:
- Reproductive Medicine
- Genetics
- Andrology
Background:
- Klinefelter syndrome (47 XXY) was historically associated with infertility.
- Advancements in testicular sperm extraction (TESE) have opened avenues for biological fatherhood in affected individuals.
Purpose of the Study:
- To review and analyze data from studies on TESE in Klinefelter syndrome patients.
- To identify factors influencing TESE success rates, particularly focusing on patient age and hormonal therapy.
Main Methods:
- Systematic review and analysis of published TESE outcome data in Klinefelter syndrome patients.
- Evaluation of prognostic factors including patient age, clinical parameters, and androgen therapy.
Main Results:
- Age is a significant prognostic factor for TESE success, with a poorer prognosis observed in patients over 30.
- Sperm retrieval rates in younger patients (under 20) appear comparable to those aged 20-30.
- TESE before age 16 does not improve outcomes and may be linked to insufficient gamete maturation.
Conclusions:
- Further research is needed to identify predictive markers for TESE success in Klinefelter syndrome.
- The impact of age and androgen therapy on sperm retrieval requires additional investigation.
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