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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

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T cell dysregulation in SLE

Klaus Tenbrock¹, Thomas Rauen²

¹Dept of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany.

Clinical Immunology (Orlando, Fla.)

|May 8, 2022

Abstract:

T helper cells aid B cells with the production of antibodies and thus play a central role in disease development of systemic lupus erythematosus (SLE). Numerous T helper cell abnormalities have been described in SLE patients that contribute to disease pathophysiology and provide suitable targets for therapeutic intervention. In addition, T effector cell also play a less well-defined role in SLE. This review focusses on underlying molecular mechanisms of different T cell alterations in SLE.

Keywords:

CD4+ T cells CD8+ T cells Foxp3 Lupus T follicular helper cells Tregs

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