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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Related Experiment Video

Updated: Sep 24, 2025

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
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Peripheral Joint Injections.

Austin Marcolina1, Kevin Vu2, George Chang Chien3

  • 1Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, 5161 Harry Hines Boulevard, Dallas, TX 75219, USA.

Physical Medicine and Rehabilitation Clinics of North America
|May 8, 2022
PubMed
Summary
This summary is machine-generated.

Peripheral joint injections offer pain relief for conditions like arthritis when conservative treatments fail. These injections aim to improve function by reducing pain, using various substances such as corticosteroids or platelet-rich plasma.

Keywords:
CorticosteroidHyaluronic acidImage guidanceJoint painLandmark guidanceMesenchymal stromal cellsPeripheral joint injectionPlatelet-rich plasma

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Area of Science:

  • Orthopedics
  • Rheumatology
  • Pain Management

Background:

  • Peripheral joint pain, often from arthritis, tendinopathy, or bursitis, frequently requires intervention beyond conservative care.
  • Chronic inflammation from trauma, autoimmune conditions, or metabolic issues underlies degenerative joint diseases like osteoarthritis and rheumatoid arthritis.
  • Joint damage leads to pain and functional limitations, necessitating advanced treatment options.

Purpose of the Study:

  • To review the role and common injectates of peripheral joint injections.
  • To highlight their use in managing joint pain unresponsive to conservative therapies.
  • To underscore their objective of pain reduction for functional improvement.

Main Methods:

  • Review of current literature on peripheral joint injections.
  • Analysis of common indications and injectates.
  • Discussion of treatment goals and outcomes.

Main Results:

  • Peripheral joint injections are a common interventional approach for joint pain.
  • They are utilized when physical therapy and oral medications are insufficient.
  • Key injectates include local anesthetics, corticosteroids, hyaluronic acid, platelet-rich plasma, and mesenchymal stromal cells.

Conclusions:

  • Peripheral joint injections are valuable for managing chronic joint pain and improving function.
  • While not curative, they facilitate concurrent physical and pharmaceutical therapies.
  • The choice of injectate depends on the specific joint condition and patient factors.