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Related Concept Videos

Drugs Acting on Autonomic Ganglia: Blockers01:28

Drugs Acting on Autonomic Ganglia: Blockers

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Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Sympathetic Pathways: Sympathetic Chain Ganglia01:20

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The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
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The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
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Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

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The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
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The greater splanchnic nerve, formed by the...
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Sympathetic Signaling01:31

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Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
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Related Experiment Video

Updated: Sep 24, 2025

Author Spotlight: Exploring Plasticity of Sympathetic Neurons
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Sympathetic Blocks for Visceral Pain.

Kevin Vorenkamp1, Peter Yi2, Adam Kemp2

  • 1Division of Pain Medicine, Duke Anesthesiology, Duke University, 2080 Duke University Road, Durham, NC 27708, USA.

Physical Medicine and Rehabilitation Clinics of North America
|May 8, 2022
PubMed
Summary
This summary is machine-generated.

Sympathetic blocks offer effective pain management for visceral pain, especially when other treatments fail. These procedures provide durable analgesia and improve quality of life for chronic and cancer pain patients.

Keywords:
Neurolytic procedureSympathetic blockVisceral painceliac plexusganglion imparsuperior hypogastric plexus

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Area of Science:

  • Pain Management
  • Interventional Pain Medicine
  • Oncology

Background:

  • Chronic and cancer-related pain often involves visceral pain.
  • Conservative care and pharmacotherapy may be insufficient or poorly tolerated.

Purpose of the Study:

  • To evaluate the role of sympathetic blocks in managing visceral pain.
  • To compare neurolytic procedures with anesthetic infusions.

Main Methods:

  • Targeting afferent visceral innervation via sympathetic ganglia.
  • Consideration of neurolytic procedures when other treatments fail.

Main Results:

  • Sympathetic blocks provide effective and durable analgesia.
  • Neurolytic procedures offer potential cost savings and avoid hardware complications.
  • Improved quality of life metrics observed.

Conclusions:

  • Interventional therapies targeting sympathetic ganglia are valuable for visceral pain.
  • These methods offer an alternative to traditional pain management strategies.