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CD8+ Tregs kill pathogenic cells to avert autoimmunity

Dan Hu1, Gopal Murugaiyan1

  • 1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

Trends in Immunology
|May 8, 2022
PubMed

Mouse Ly49+CD8+ regulatory T cells (Tregs) can subdue autoreactive CD4+ T cells to suppress autoimmunity. Recently, Li et al. demonstrated that killer-cell immunoglobulin-like receptor (KIR)+CD8+ T cells are the human equivalent of Ly49+CD8+ regulatory T cells and kill pathogenic CD4+ T cells, which can be increased in certain human autoimmune diseases and viral infections.

Keywords:
CD8(+) TregsT cellsautoimmunity

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