[Establishment method and experimental application of the mouse model of severe asthma]

Severe asthma remains the bottleneck of clinical treatment. In order to deeply analyze the pathogenesis of severe asthma, so as to develop the new targeted drugs and evaluate the curative effects, it is urgent to establish an ideal animal model of severe asthma, which is of great significance to simulate the pathophysiological and clinical characteristics of patients with severe asthma and study the potential therapeutic targets of severe asthma. Here we summarized the establishment method and experimental application of the mouse model of severe asthma.