Allergy clinic patients' drug hypersensitivity

Area of Science:

• Allergy and Immunology
• Pharmacology
• Clinical Medicine

Background:

• Drug hypersensitivity reactions (DHR) are frequent reasons for allergology consultations.
• Accurate medical history and diagnostic testing are crucial for DHR assessment.

Purpose of the Study:

• To retrospectively evaluate patients with preliminary DHR diagnoses.
• To assess the utility of NSAID hypersensitivity classification in outpatient settings.
• To analyze skin, provocation, and drug tolerance test results.

Main Methods:

• Analysis of 501 patient records with preliminary DHR diagnoses (2011-2019).
• Evaluation of diagnostic and drug tolerance tests in 269 patients (2009-2019).

Main Results:

• NSAIDs (67.5%) and antibiotics (54.3%) were the most suspected DHR causes.
• Mixed pattern hypersensitivity was most prevalent for NSAIDs; delayed reactions with skin symptoms for beta-lactams.
• NSAIDs and antibiotics were common causes of anaphylaxis.

Conclusions:

• Medical history is foundational for classifying suspected DHR.
• Classification of hypersensitivity aids in the diagnostic process for DHR.