Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

Recently, effervescent tablets (ETs) have become increasingly popular with patients in clinics due to their fast disintegration by acid-alkali reactions in water. However, certain undesirable properties of ETs (e.g., sticking and high hygroscopicity) can limit their production and application. In particular, frequent sticking always severely decreases the tablet quality and productivity. Therefore, in this study, polyvinylpyrrolidone (PVP) at different usage levels, grades, or spray solution concentrations was coated onto the surfaces of both acidic and alkaline granules of ETs by means of the fluid-bed coating technique. In terms of fully characterized powder, tableting, and tablet properties, the following points were concluded: (i) a uniform coating of PVP onto the surfaces of these two granules not only resolved the sticking problem, but also effectively decreased the hygroscopicity and enhanced the compactibility; (ii) the improvements increased with an increase in the PVP content or PVP molecular weight and a decrease in the PVP spray solution concentration owing to the formation of an increasingly even and cohesive coating layer; (iii) the process of fluid-bed coating was not the simple superposition or simple mixing of two different materials' properties; (iv) the coating process did not cause significant influences on the disintegration time of ETs. Overall, it is fairly meaningful to further promote the development of ETs in practice since these problems have been overcome.