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Biomarkers, Clinical Course, and Individual Needs in COPD Patients in Primary Care: The Study Protocol of the
Lena Lundh1,2, Kjell Larsson3, Anders Lindén4,5
1Academic Primary Health Care Centre, Stockholm County Council, Stockholm, Sweden.
Background:
To facilitate effective personalized medicine, primary health care needs better methods of assessing and monitoring chronic obstructive pulmonary disease (COPD).
Aim:
This cohort study aims to investigate how biomarkers relate to clinical characteristics and COPD patients' subjective needs over time.
Methods:
Patients (n=750) in different COPD severity according to the GOLD criteria and age- and sex-matched controls (n=750) will be recruited over a period of 5 years from 15 primary health care centers in Region Stockholm, Sweden, and followed for 10 years in the first instance. Data on patients' subjective needs will be collected via telephone/email, data on clinical/physiological variables (eg, symptoms, exacerbations, comorbidities, medications, smoking habits, lung function) from existing databases that are based on medical records, and data on biomarkers via repeated blood sampling. Quantitative and qualitative methods will be used. Initial results are expected after 2 years (feasibility test), and a larger body of evidence after 5 years.
Discussion:
The study is expected to provide definitive and clinically useful scientific evidence about how biomarkers relate to clinical variables and patients' subjective needs. This new evidence will facilitate accurate, and personalized COPD management by the use of valid biomarkers. It will provide useful tools for primary care professionals and may facilitate optimal self-management.
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