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Updated: Sep 24, 2025
08:58
Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression
Published on: April 18, 2025
673
Discovering Common Pathophysiological Processes between COVID-19 and Cystic Fibrosis by Differential Gene Expression
Md Tanvir Hasan1, Lway Faisal Abdulrazak2, Mohammad Khursheed Alam3,4,5
1Department of Software Engineering, Daffodil International University (DIU), Ashulia, Savar, Dhaka 1341, Bangladesh.
Biomed Research International
|May 9, 2022
Summary
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) gene expression in cystic fibrosis (CF) reveals 8 shared genes. This transcriptomic analysis identifies pathways and potential drug targets like IMIQUIMOD for SARS-CoV-2 and CF patients.
Area of Science:
- Genomics
- Virology
- Medical Genetics
Background:
- Coronaviruses, including SARS-CoV-2, cause respiratory infections in humans.
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
- Understanding the interplay between SARS-CoV-2 and CF is crucial for patient management.
Purpose of the Study:
- To perform a comparative transcriptomic analysis of SARS-CoV-2 and cystic fibrosis (CF).
- To identify shared differentially expressed genes and associated biological pathways.
- To explore potential therapeutic targets for co-infected individuals.
Main Methods:
- Comparative transcriptomic analysis of gene expression profiles.
- Identification of differentially expressed genes (DEGs) between SARS-CoV-2 and CF.
- Gene ontology and pathway enrichment analysis.
- TF-miRNA association network construction.
Main Results:
- Identified 8 concordant genes shared between SARS-CoV-2 and CF.
- Pathway enrichment analysis revealed involvement of innate immunity, Toll-like receptor signaling, and inflammatory pathways.
- TF-miRNA network identified interconnections relevant to co-infection.
- IMIQUIMOD and raloxifene identified as significant drug targets.
Conclusions:
- Transcriptomic analysis provides insights into SARS-CoV-2 response in the context of CF.
- Identified pathways and gene networks offer potential for novel therapeutic strategies.
- Drug targets like IMIQUIMOD and raloxifene warrant further investigation for treating co-infection.
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