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Updated: Sep 24, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Microneedle-Based Device for Biological Analysis.

Huiting Lu1, Shah Zada2, Lingzhi Yang2

  • 1Department of Chemistry, School of Chemistry and Biological Engineering, University of Science & Technology Beijing, Beijing, China.

Frontiers in Bioengineering and Biotechnology
|May 9, 2022
PubMed
Summary
This summary is machine-generated.

Microneedle (MN)-based devices offer a noninvasive alternative to traditional blood sampling for disease diagnosis. This review explores MN fabrication materials, device types, and applications, highlighting future perspectives.

Keywords:
bio-signal recordingbiological analysisbiomarker capturedetectionmicroneedlestransdermal sampling

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Diagnostics

Background:

  • Traditional blood sampling is invasive and requires professional administration.
  • Microneedle (MN)-based devices present a less invasive alternative for biological analysis.
  • Growing interest in noninvasive diagnostic and monitoring tools.

Purpose of the Study:

  • To review materials used in fabricating microneedles (MNs).
  • To categorize MN-based devices into four classes: transdermal sampling, biomarker capture, analyte detection/monitoring, and bio-signal recording.
  • To discuss design strategies and applications of MN-based devices.

Main Methods:

  • Literature review of microneedle fabrication materials.
  • Categorization of MN devices based on function and application.
  • Analysis of design strategies and performance in various applications.

Main Results:

  • Introduction to diverse materials for MN fabrication.
  • Classification of MN devices into four functional categories.
  • Detailed discussion of design, applications, and future outlook for MN technology.

Conclusions:

  • Microneedle technology offers a promising noninvasive approach for biological sample collection and analysis.
  • MN devices are versatile, applicable in diagnostics, monitoring, and bio-signal recording.
  • Continued research and development in MN materials and designs will expand their clinical utility.