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Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan.
Beniamino Palmieri1,2, Antonio Manenti1,2,3, Francesca Galotti1,2,4
1Medico Cura Te Stesso Onlus, Modena, Italy.
Corynebacterium parvum administration enhanced innate immunity and adaptive immune response in 4000 immunocompromised patients. This treatment improved patient health outcomes and immune function, suggesting its potential for long-standing anti-infectious resistance.
Area of Science:
- Immunology
- Infectious Disease
Background:
- 4000 fragile, immune-depressed, and multimorbid patients received Corynebacterium parvum (C. parvum) for immune enhancement.
- The study aimed to assess C. parvum's efficacy in improving innate and adaptive immune responses for long-standing anti-infectious resistance.
Purpose of the Study:
- To evaluate the safety and efficacy of C. parvum in supporting immunocompromised individuals.
- To investigate the impact of C. parvum on immune function and clinical outcomes in a large patient cohort.
Main Methods:
- Retrospective survey of 4000 patients receiving subcutaneous C. parvum injections.
- Follow-up up to 6 months, assessing health status via SF-36 questionnaire and telemedicine.
Main Results:
- Significant improvements in mental/physical functioning, general health, social role, vitality, and pain reduction (p < 0.03).
- Rapid symptom improvement in herpetic eruptions and neuralgia; recovery/frequency reduction in cystitis/prostatitis.
- Increased lymphocyte count (p < 0.01), high SARS-CoV-2 antibody levels in some patients, and benign COVID-19 recovery.
Conclusions:
- C. parvum is safe and effective for immunocompromised patients during epidemics/pandemics.
- Results support C. parvum's role in enhancing resistance to infections and complications.
- Further double-blind placebo-controlled studies are warranted to confirm these findings.
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