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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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Risk Factors of Chronic Kidney Disease in Chronic Hepatitis B: A Hospital-based Case-control Study from China

Yunqi Liu1,2, Ximei Wang1,3, Fuping Xu4

  • 1Department of Nephropathy, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Journal of Clinical and Translational Hepatology
|May 9, 2022
PubMed

Insights

Chronic kidney disease (CKD) risk factors in hepatitis B virus (HBV) infection were identified. HBeAg-positive status, dyslipidemia, and hypertension increase CKD risk, while longer HBV duration and lower HBsAg levels are protective.

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a common complication in patients with chronic hepatitis B virus (HBV) infection.
  • However, the specific risk factors for CKD in this population remain incompletely understood.
  • This study investigates these risk factors in a Chinese cohort.

Purpose of the Study:

  • To identify and analyze the risk factors associated with the incidence of CKD in individuals with chronic HBV infection.
  • To provide insights into the pathogenesis and prevention of CKD in this specific patient group.

Main Methods:

  • A hospital-based cross-sectional study was conducted in northern China from January 2013 to December 2017.
  • 94 CKD patients with chronic HBV infection were compared with 548 age- and sex-matched HBV patients without CKD.
  • Univariate and multivariate regression analyses were employed to determine independent risk and protective factors.

Main Results:

  • HBeAg-positive status (OR=2.099), dyslipidemia (OR=3.025), and hypertension (OR=12.523) were identified as independent risk factors for CKD.
  • Longer duration of HBV infection (≥240 months) (OR=0.401), lower Log10 HBsAg levels (OR=0.514), and coronary heart disease (OR=0.078) demonstrated protective effects.
  • These associations remained significant after adjusting for diabetes mellitus, hypertension, and coronary heart disease.

Conclusions:

  • HBeAg-positive status, dyslipidemia, and hypertension are significant risk factors for CKD in chronic HBV-infected individuals.
  • Longer HBV infection duration and lower HBsAg levels may offer protection against CKD development.
  • These findings highlight key factors for managing CKD risk in the HBV population.
Abstract

Keywords:
Case-control studyChronic kidney diseaseCross-sectional studyHepatitis B virusRisk factors

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