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Clinical Manifestations:

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Updated: Sep 24, 2025

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

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Published on: May 17, 2024

Prolonged Large Seroma Formation after Breast-Conserving Therapy.

Shuhei Suzuki¹, Shoji Oura¹, Shinichiro Makimoto¹

¹Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada-city, Japan.

Case Reports in Oncology

|May 9, 2022

Summary

A persistent seroma after breast cancer surgery and radiotherapy can form a thick capsule. Capsulectomy successfully treated this encapsulated seroma, offering a solution for this rare adverse event.

Keywords:

Breast cancer Capsulectomy Long-lasting seroma Radiotherapy

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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

Area of Science:

Oncology
Surgical Oncology
Radiation Oncology

Background:

A 78-year-old obese woman with breast cancer underwent breast-conserving surgery and axillary lymph node dissection.
Due to prior taxane chemotherapy for gastric cancer, adjuvant chemotherapy was omitted, and radiotherapy was initiated 39 days post-operation.

Observation:

Significant seroma formation occurred, extending from the axilla into the breast parenchyma.
Initial aspiration therapies and later minocycline injection failed to resolve the persistent, encapsulated seroma.
The patient presented with a large, tense seroma 7 months after surgery, requiring intervention.

Findings:

Capsulectomy was performed on the encapsulated seroma, revealing a resected capsule measuring 110 x 45 mm.
Pathological examination showed the capsule was primarily fibrous tissue with inflammatory changes.
Post-capsulectomy, the patient experienced prompt wound healing without complications.

Implications:

This case highlights a rare, unfavorable radiation-induced adverse event following breast-conserving therapy.
Breast surgeons and radiation oncologists should be aware of the potential for encapsulated seroma formation.
Capsulectomy may be an effective treatment for persistent, encapsulated seromas post-breast cancer treatment.