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Cytokine Based Immunotherapy for Cancer and Lymphoma: Biology, Challenges and Future Perspectives

Suheil Albert Atallah-Yunes1, Michael J Robertson1

  • 1Department of Hematology and Medical Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.

Frontiers in Immunology
|May 9, 2022
PubMed

Insights

Cytokines show promise in cancer immunotherapy, especially when combined with other treatments. Recent advances in genetic engineering and immunotherapy are reviving interest in using cytokines to fight cancer, particularly lymphoma.

Area of Science:

  • Immunology
  • Cancer Biology
  • Biotechnology

Background:

  • Cytokines are key regulators of immune responses against cancer.
  • Previous use of cytokines as single agents in cancer immunotherapy yielded limited clinical success.
  • Advances in biotechnology and immunotherapy have renewed interest in cytokine-based cancer treatments.

Purpose of the Study:

  • To review immunostimulatory cytokines with demonstrated anticancer activity.
  • To focus on cytokines studied in lymphoma treatment.
  • To highlight recent advancements with clinical relevance.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Focus on immunostimulatory cytokines.
  • Analysis of advancements in genetic engineering, synthetic biology, and cellular therapy.

Main Results:

  • Cytokines exhibit antitumor activity in preclinical cancer models.
  • Combinations of cytokines with other immunotherapeutics show potential.
  • Recent technological advances are enabling novel cytokine-based therapeutic strategies.

Conclusions:

  • Cytokines hold renewed potential as anticancer agents, particularly in combination therapies.
  • Further research into cytokine applications, especially for lymphoma, is warranted.
  • Advancements in biotechnology are crucial for realizing the clinical potential of cytokines in cancer treatment.
Keywords:
cancercytokinesimmunotherapyinterleukinslymphoma

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