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Alternations in Dynamic and Static Functional Connectivity Density in Chronic Smokers.
Zhengui Yang1,2,3,4,5,6,7, Mengmeng Wen1,2,3,4,5,6,7, Yarui Wei1,2,3,4,5,6,7
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
This study reveals altered brain connectivity in smokers using dynamic functional connectivity density (dFCD). Smokers showed distinct patterns in visual and other brain regions, correlating with smoking severity.
Area of Science:
- Neuroimaging
- Neuroscience
- Addiction Research
Background:
- Previous studies suggest abnormal brain functional coordination in smokers.
- Resting-state functional connectivity (rsFC) has limitations in capturing comprehensive brain connectivity changes.
Purpose of the Study:
- To investigate whole-brain functional coordination in chronic smokers using functional connectivity density (FCD).
- To explore dynamic changes in brain integration using dynamic FCD (dFCD).
Main Methods:
- Recruited 120 chronic smokers and 56 non-smokers.
- Utilized static FCD and dynamic FCD (dFCD) to assess whole-brain functional coordination.
- Analyzed differences in brain connectivity patterns between groups and smoking severities.
Main Results:
- Shared aberrant functional connectivity in visual areas was observed in both static and dFCD analyses.
- Smokers exhibited decreased dFCD in the visual cortex and left precuneus.
- Increased dFCD was found in the right orbitofrontal cortex, left caudate, right putamen, and left thalamus in smokers.
- dFCD variations differed between heavy and light smokers and correlated positively with smoking behaviors.
Conclusions:
- Dynamic FCD (dFCD) reveals subtle brain alterations in chronic smokers.
- Brain connectivity changes are associated with smoking severity.
- Combining static and dFCD offers a deeper understanding of smoking-induced brain modifications.
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