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Related Experiment Video

Updated: Sep 24, 2025

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
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Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors.

Tianwei Tang1, Yinghuan Liu1, Ying Jiang1,2

  • 1College of Chemistry, Beijing Normal University, Beijing, 100875 P. R. China.

Chemical Research in Chinese Universities
|May 9, 2022
PubMed
Summary

Electrochemical aptamer-based (E-AB) sensors offer high selectivity and sensitivity for biosensing. This review covers recent advancements in E-AB sensor fabrication and detection strategies for biological applications.

Keywords:
AptamerBiological systemBiomolecular recognitionElectrochemical biosensor

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Biosensor Technology

Background:

  • Biosensors are crucial for understanding physiological activities and diseases at the molecular level.
  • Electrochemical aptamer-based (E-AB) sensors combine aptamer selectivity with electrochemical sensitivity for biological measurements.

Purpose of the Study:

  • To review the latest developments in electrochemical aptamer-based sensors.
  • To focus on sensor fabrication modification strategies and analyte detection methods.
  • To discuss future challenges and prospects for E-AB sensor technology.

Main Methods:

  • Review of recent literature on electrochemical aptamer-based sensor fabrication.
  • Analysis of various modification strategies for sensor surfaces.
  • Examination of sensing strategies for different analyte sizes in biological systems.

Main Results:

  • Summarizes recent advancements in E-AB sensor technology.
  • Highlights diverse modification and sensing strategies.
  • Identifies key trends in the field.

Conclusions:

  • E-AB sensors are a promising platform for sensitive and selective biosensing.
  • Further research is needed to address current challenges and unlock future potential.
  • Continued development will enhance their application in biological and medical diagnostics.