Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-gestational choriocarcinoma presenting as cervical lymphadenopathy in a male patient: a case report.

Frontiers in oncology·2026
Same author

Emerging trends and hotspots in lung-protective ventilation from 2006 to 2025: a bibliometric analysis.

Journal of thoracic disease·2026
Same author

Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export.

Signal transduction and targeted therapy·2026
Same author

"Dual-lock"-controlled activatable nanotheranostics for chemiluminescence resonance energy transfer (CRET)-driven enhanced photoimmunotherapy.

Journal of materials chemistry. B·2026
Same author

Proteomic analysis reveals lipid metabolism disruption and key targets in ARPE-19 cells after RNF13 knockdown.

Scientific reports·2026
Same author

Tumor microenvironment-adaptive nanocatalysts: harnessing pH gradients for selective and synergistic cancer therapy.

Journal of materials chemistry. B·2026

Related Experiment Video

Updated: Sep 24, 2025

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy
10:51

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Published on: August 28, 2013

10.9K

Single pulse heating of a nanoparticle array for biological applications.

Chen Xie1, Peiyuan Kang1, Johan Cazals1

  • 1Department of Mechanical Engineering, University of Texas at Dallas, 800 West Campbell Road EW31, Richardson, Texas 75080, USA.

Nanoscale Advances
|May 9, 2022
PubMed
Summary

This study models nanoparticle (NP) array heating, finding nanoscale-confined heating (NCH) can target protein denaturation. However, it does not selectively activate TRPV1 channels, with duration and NP concentration being key factors.

More Related Videos

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating
08:04

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating

Published on: February 20, 2016

13.8K
Studying the Effects of Temperature on the Nucleation and Growth of Nanoparticles by Liquid-Cell Transmission Electron Microscopy
07:02

Studying the Effects of Temperature on the Nucleation and Growth of Nanoparticles by Liquid-Cell Transmission Electron Microscopy

Published on: February 17, 2021

4.3K

Related Experiment Videos

Last Updated: Sep 24, 2025

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy
10:51

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Published on: August 28, 2013

10.9K
Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating
08:04

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating

Published on: February 20, 2016

13.8K
Studying the Effects of Temperature on the Nucleation and Growth of Nanoparticles by Liquid-Cell Transmission Electron Microscopy
07:02

Studying the Effects of Temperature on the Nucleation and Growth of Nanoparticles by Liquid-Cell Transmission Electron Microscopy

Published on: February 17, 2021

4.3K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Computational Biology

Background:

  • Nanomaterials convert excitation energy into heat, crucial for biomedical applications.
  • Two heating modes exist: nanoscale-confined heating (NCH) and macroscale-collective heating (MCH).
  • The protein-level biological response to NP heating remains poorly understood.

Purpose of the Study:

  • To computationally model single-pulsed NP array heating.
  • To investigate the resulting protein denaturation and activation.
  • To define parameters for targeted protein denaturation.

Main Methods:

  • Development of a computational model for NP array heating.
  • Systematic investigation of single-pulsed heating effects.
  • Analysis of protein denaturation and TRPV1 channel activation.

Main Results:

  • NCH shows potential for targeted protein denaturation.
  • Nanoparticle heating does not result in nanoscale selective TRPV1 channel activation.
  • Excitation duration and NP concentration are critical for targeted protein denaturation.
  • Quantified boundaries for targeted protein denaturation were defined using heating power, duration, and NP concentration.

Conclusions:

  • The study enhances understanding of NCH and MCH under physical constraints.
  • Provides guidance for customizing NP heating in biomedical platforms.
  • Highlights the importance of specific parameters for achieving desired protein denaturation effects.