Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiology of the hormetic effect.

J R Totter

    Health Physics
    |May 1, 1987
    PubMed
    Summary

    Low-dose ionizing radiation may offer hormetic benefits, similar to food restriction. This exposure is interpreted by the body as excess food intake, potentially increasing longevity by reducing caloric consumption.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pernicious Anemia and Related Anemias Treated with Vitamin B(12).

    Transactions of the American Clinical and Climatological Association·2011
    Same author

    The influence of a strepogenin concentrate on the metabolism of glutamic acid by Streptococcus faecalis.

    The Journal of biological chemistry·2010
    Same author

    The relationship between vitamin M and the Lactobacillus casei factor.

    The Journal of biological chemistry·2010
    Same author

    Studies on the function of pteroylglutamic acid in Streptococcus faecalis.

    Federation proceedings·2010
    Same author

    The inhibition of conjugase by a polypeptide of p-aminobenzoic acid.

    Federation proceedings·2010
    Same author

    The relation of pteroylglutamic acid to metal-porphyrin enzymes.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010

    Area of Science:

    • Radiobiology
    • Endocrinology
    • Gerontology

    Background:

    • Hormetic effects of ionizing radiation are understudied due to a lack of explanatory hypotheses.
    • Food restriction in animals shows parallels with low-level radiation exposure, including increased longevity and altered longevity variance.

    Purpose of the Study:

    • To propose a hypothesis explaining the beneficial (hormetic) effects of low-level ionizing radiation.
    • To explore the relationship between food restriction, ionizing radiation, and physiological changes affecting longevity.

    Main Methods:

    • Literature review examining studies on food restriction and low-level ionizing radiation.
    • Interpretation of physiological changes through the lens of oxygen radical flux and endocrine balance.

    Main Results:

    • Low-level, low-linear energy transfer (LET) whole-body ionizing radiation exposure mimics food restriction's effects on longevity and its variance.
    • This radiation exposure is perceived by the body as increased food availability, leading to reduced caloric intake and potentially increased longevity.
    • The observed effects are linked to alterations in the steady-state flux of oxygen radicals impacting endocrine balance.

    Conclusions:

    • Low-level ionizing radiation may trigger adaptive responses similar to food restriction, suggesting a hormetic effect.
    • The body's interpretation of radiation as excess food intake provides a potential mechanism for increased longevity.
    • Understanding these interactions is crucial for developing comprehensive radiobiological theories.

    Related Experiment Videos