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Pleural Effusion II: Symptoms and Management01:28

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Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
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Pleural Effusion I: Introduction01:25

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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
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Pleural Disorders: Types and Brief Description01:30

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The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
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Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
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Related Experiment Video

Updated: Sep 24, 2025

A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
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Dasatinib-Induced Bilateral Pleural Effusions.

Taha F Rasul1, Gabriel Motoa2, Robert C Flowers2

  • 1Internal Medicine, University of Miami Miller School of Medicine, Miami, USA.

Cureus
|May 9, 2022
PubMed
Summary
This summary is machine-generated.

This case study highlights a rare instance of bilateral pleural effusions and ascites in a patient treated with dasatinib for chronic myeloid leukemia (CML). It suggests dasatinib may induce these fluid accumulations, even with unclear ascites origins.

Keywords:
bilateralchronic myeloid leukemiadasatinibpleural effusionstreatment

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Area of Science:

  • Oncology
  • Internal Medicine
  • Pharmacology

Background:

  • Fluid accumulation, such as pleural effusions and ascites, can stem from various causes.
  • Accurate diagnosis relies on detailed patient history and comprehensive fluid analysis.

Observation:

  • A 60-year-old male patient with chronic myeloid leukemia (CML) on dasatinib, history of stroke, liver disease, substance use disorders, and hypertension presented with bilateral pleural effusions and ascites.
  • Pleural fluid analysis revealed an exudative effusion, while ascitic fluid was transudative.

Findings:

  • Extensive workup attributed the bilateral pleural effusions to dasatinib therapy.
  • Dasatinib was also suspected to contribute to the ascites, though its role remained unclear.
  • This is the first reported case of bilateral tyrosine kinase inhibitor (TKI)-induced pleural effusions with concurrent ascites of uncertain etiology.

Implications:

  • Peripheral edema and pleural effusions are known side effects of TKIs.
  • This case expands the understanding of potential TKI-induced fluid accumulation, emphasizing the need for vigilant monitoring in patients on these therapies.
  • Further research may elucidate the mechanisms behind TKI-associated ascites.