Intussusception Caused by Peutz-Jeghers Syndrome

Area of Science:

• Gastroenterology
• Genetics
• Surgical Oncology

Background:

• Peutz-Jeghers syndrome is an inherited disorder characterized by hamartomatous polyps in the gastrointestinal tract.
• It significantly increases the risk of various cancers, including gastrointestinal and breast malignancies.
• Intussusception is a common complication, often requiring surgical intervention.

Observation:

• A 20-year-old female with a family history of Peutz-Jeghers syndrome presented with recurrent abdominal pain.
• She experienced multiple episodes of small bowel intussusception, necessitating two small bowel resections and tumor removals.
• The case highlights the complex management challenges associated with this syndrome.

Findings:

• Peutz-Jeghers syndrome predisposes individuals to repeated gastrointestinal complications like intussusception.
• Surgical interventions, including resections, may be required multiple times.
• Tumor surveillance is essential for early detection and management of neoplastic changes.

Implications:

• Close, long-term follow-up is vital for patients with Peutz-Jeghers syndrome.
• Monitoring tumor size and number can prevent surgical complications and anemia.
• Early detection of carcinomatous changes through regular surveillance improves patient outcomes.