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Intussusception Caused by Peutz-Jeghers Syndrome
Harsha S Sreemantula1, Crystal A Joseph2, Faraz Jamal3
1Internal Medicine, Mercy Catholic Medical Center, Darby, USA.
Insights
Patients with Peutz-Jeghers syndrome require vigilant monitoring due to recurrent intussusception and tumor development. Regular follow-ups are crucial for managing complications and preventing cancer.
Area of Science:
- Gastroenterology
- Genetics
- Surgical Oncology
Background:
- Peutz-Jeghers syndrome is an inherited disorder characterized by hamartomatous polyps in the gastrointestinal tract.
- It significantly increases the risk of various cancers, including gastrointestinal and breast malignancies.
- Intussusception is a common complication, often requiring surgical intervention.
Observation:
- A 20-year-old female with a family history of Peutz-Jeghers syndrome presented with recurrent abdominal pain.
- She experienced multiple episodes of small bowel intussusception, necessitating two small bowel resections and tumor removals.
- The case highlights the complex management challenges associated with this syndrome.
Findings:
- Peutz-Jeghers syndrome predisposes individuals to repeated gastrointestinal complications like intussusception.
- Surgical interventions, including resections, may be required multiple times.
- Tumor surveillance is essential for early detection and management of neoplastic changes.
Implications:
- Close, long-term follow-up is vital for patients with Peutz-Jeghers syndrome.
- Monitoring tumor size and number can prevent surgical complications and anemia.
- Early detection of carcinomatous changes through regular surveillance improves patient outcomes.
Abstract:
A 20-year-old female patient with a family history significant for Peutz-Jeghers syndrome presented to the hospital multiple times with complaints of abdominal pain. On the initial visit to the hospital, the patient underwent small bowel resection for small bowel obstruction secondary to intussusception, following which she visited the hospital again one year later for similar complaints and underwent reduction of multiple points of intussusception of the small bowel without any resection of the same. Eventually, the patient underwent resection of the small bowel for the second time, along with tumor resections. The importance of follow-up in patients with Peutz-Jeghers is particularly essential, in part, because it is vital to monitor the tumors, their size, and number to prevent surgical intestinal complications, anemia, and also to eventually monitor for carcinomatous changes.
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