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Updated: Sep 24, 2025

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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Plasminogen Activator Inhibitor-1 4G/5G Polymorphism Presenting as Recurrent Ischemic Stroke: The Microthrombi Shower

John Dayco1, Taha Ataya1, Chad Tidwell1

  • 1Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.

Cureus
|May 9, 2022
PubMed

Insights

A rare genetic variant, plasminogen activator inhibitor-1 polymorphism, was identified in a patient with recurrent strokes. This finding highlights a potential link between genetic factors and cerebrovascular thrombosis risk.

Area of Science:

  • * Medical Case Study
  • * Genetics and Thrombosis

Background:

  • * Physicians should investigate unusual clinical presentations for underlying pathological causes.
  • * Recurrent micro thromboembolic strokes at a young age warrant deeper investigation.

Observation:

  • * A 41-year-old male presented with recurrent micro thromboembolic strokes.
  • * This presentation is atypical for the patient's age, prompting a search for the pathological process.

Findings:

  • * A rare plasminogen activator inhibitor-1 (PAI-1) polymorphism was identified.
  • * This genetic polymorphism is associated with an increased risk of cerebrovascular thrombosis.
  • * The defect involves the inhibition of tissue plasminogen activator protein.

Implications:

  • * This case highlights an under-explored genetic factor in cerebrovascular events.
  • * Future research may focus on PAI-1 polymorphism for risk stratification.
  • * Potential for developing novel pharmacological treatments targeting this pathway.
Keywords:
congenital abnormalitiesembolic stroke of undetermined sourcemagnetic resonance angiography (mra)magnetic resonance imagingthrombotic coagulopathy

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