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Lady with Long Eyelashes…!

Soumya S Inamadar¹, N S Praveen Kumar¹

¹Department of Endocrinology, Care Hospitals, Hyderabad, Telangana, India.

International Journal of Trichology

|May 9, 2022

Summary

This summary is machine-generated.

Erlotinib, a cancer drug, can cause significant eyelash growth (trichomegaly) and increased facial hair (hypertrichosis) as side effects. This case highlights the importance of considering medication history in diagnosing such hair growth abnormalities.

Keywords:

Carcinoma lung epidermal growth factor receptor erlotinib hirsutism trichomegaly

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Area of Science:

Dermatology
Oncology
Pharmacology

Background:

Chemotherapeutic agents, particularly Epidermal Growth Factor Receptor (EGFR) inhibitors, are increasingly recognized for their diverse side effect profiles.
Non-small cell lung carcinoma treatment often involves targeted therapies like Erlotinib, necessitating a thorough understanding of their cutaneous manifestations.

Observation:

A 60-year-old postmenopausal woman presented with a progressive eight-year history of markedly elongated, thick, and curly eyelashes (trichomegaly).
The patient also exhibited increased vellus hair on her upper lip and chin (hypertrichosis).
A key historical detail was the patient's long-term use of Erlotinib for non-small cell lung carcinoma.

Findings:

Erlotinib, an EGFR inhibitor, disrupts hair growth by interfering with the anagen to telogen transition, leading to aberrant hair shaft elongation.
Trichomegaly typically manifests 2-5 months after initiating EGFR inhibitor therapy.
The observed hypertrichosis in other facial areas is a known association with EGFR inhibitors.

Implications:

Recognizing drug-induced trichomegaly and hypertrichosis can significantly reduce unnecessary diagnostic work-ups.
This case underscores the critical importance of comprehensive patient history, including detailed medication review, in clinical practice.
Awareness of these side effects is crucial for managing potential complications such as eyelid infections or corneal ulceration.