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Updated: Sep 24, 2025

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
Published on: October 24, 2018
Enhanced enantioseparation of drugs by capillary electrochromatography with a L-cysteine functionalized gold
Pandeng Miao1,2, Ying Xi1,2, Zijie Feng1,2
1Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, Jiangsu, P. R. China. du_yingxiang@126.com.
Abstract:
Nanoparticles, which have unique properties, have attracted growing attention in enantiomeric separation nowadays. In this paper, an L-cysteine functionalized gold nanoparticle (L-Cys-GNP) based capillary column was prepared and applied in separating drug enantiomers in capillary electrochromatography (CEC) with lactobionic acid (LA) as a chiral selector. Compared with bare fused-silica capillary columns, the capillary columns modified with L-Cys-GNPs showed excellent chiral separation performance. A series of parameters affecting the enantiomeric separation were systematically investigated.
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