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Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...

Renal Corpuscle

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Related Experiment Video

Updated: Sep 24, 2025

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

MicroRNAs in kidney development and disease.

Débora Malta Cerqueira^1,2, Maliha Tayeb^1,2, Jacqueline Ho^1,2

¹Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

|May 9, 2022

Summary

MicroRNAs (miRNAs) are small RNAs crucial for kidney development. Their dysregulation is linked to kidney diseases, suggesting potential as biomarkers and therapeutics.

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Last Updated: Sep 24, 2025

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

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Published on: November 30, 2013

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

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Published on: September 11, 2020

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

Area of Science:

Molecular Biology
Developmental Biology
Genetics

Background:

MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression posttranscriptionally.
miRNAs are vital for kidney morphogenesis and function in various renal cell types.
Altered miRNA expression is associated with congenital kidney and urinary tract anomalies and Wilms tumor.

Purpose of the Study:

To review miRNA biogenesis and function.
To detail the role of miRNAs in kidney development and disease.
To explore miRNA potential as biomarkers and therapeutics.

Main Methods:

Literature review of miRNA research.
Analysis of miRNA involvement in kidney development.
Examination of miRNA roles in congenital kidney diseases.

Main Results:

miRNAs regulate key genes in kidney morphogenesis.
miRNA dysregulation contributes to developmental kidney disorders.
Specific miRNAs are implicated in congenital anomalies and Wilms tumor.

Conclusions:

miRNAs are essential regulators of kidney development.
miRNA expression patterns offer insights into developmental kidney diseases.
miRNAs show promise as diagnostic biomarkers and therapeutic targets for kidney disorders.